Pentamidine isethionate 주사제(품명: 화이자펜타미딘 이세티온산염주 300mg)

기준 내용

허가사항 범위 내에서 투여 시 요양급여 함을 원칙으로 하며, 허가사항 범위를 초과하여 아래와 같은 기준으로 투여 시에도 요양급여를 인정함.

가. 투여대상 주폐포자충폐렴(Pneumocystis jiroveci(Formerly P. carinii) pneumonia) 예방이 필요한 인체면역결핍바이러스(HIV), 선천성 면역결핍 질환, 중증 단백영양실조, 장기이식, 지속적인 CD4 Chapter 341. Pneumocystis Pneumonia

· Harrison's Principles of Internal Medicine, 19e, 2015 > 244: Pneumocystis Infections

· Fishman's Pulmonary Diseases and Disorders, 5e, 2015 > Chapter 135: Pneumocystis Pneumonia

· Guidelines for the prevention and treatment of opportunistic infections in HIV- infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America.

· 국내 HIV 감염인의 HIV/AIDS 진단 및 치료에 관한 임상진료지침 권고안: 2015년 개정판, 질병관리본부

· Martin SI, et al. Pneumocystis pneumonia in solid organ transplantation. American Journal of Transplantation 2013;13 Suppl 4:272-9.

· Stern A, et al. Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients. Cochrane Database of Systematic Reviews 2014, Issue 10. Art. No.: CD005590. DOI: 10.1002/14651858.CD005590.pub3.

· HEFZIBA GREEN, et al. Prophylaxis of Pneumocystis Pneumonia in Immunocompromised Non·HIV-Infected Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials. Mayo Clin Proc. 2007;82(9):1052-1059

· Jiang X, Mei X, Feng D, Wang X (2015) Prophylaxis and Treatment of Pneumocystis jiroveci Pneumonia in Lymphoma Patients Subjected to Rituximab-Contained Therapy: A Systemic Review and Meta-Analysis. PLoS ONE 10(4): e0122171. doi:10.1371/ journal.pone. 0122171

· Marras TK1, et al. Aerosolized pentamidine prophylaxis for Pneumocystis carinii pneumonia after allogeneic marrow transplantation. Transpl Infect Dis. 2002 Jun;4(2):66-74.

· Laila Mikaelsson, et al. Pneumocystis pneumonia - a retrospective study 1991-2001 in Gothenburg, Sweden. Journal of Infection (2006) 53, 260-265