Aspirin 25mg + Dipyridamole 200mg경구제(품명 : 아디녹스캡슐 등)
기준 내용
허가사항 범위(뇌의 일과성 허혈 또는 혈전에 의한 허혈성 뇌졸중을 경험한 환자의 뇌졸중 재발에 대한 위험성 감소) 내에서 투여 시 요양급여를 인정함.
고시 신설 사유
신규 등재 예정인 뇌졸중치료제에 대해 교과서, 가이드라인, 학회의견 등을 고려하여 허가 범위 내에서급여 인정함.
관련문헌 등 15줄
· Pharmacotherapy: A Pathophysiologic Approach. 10th Edition. 2017.
· Goldman-Cecil Medicine. 25th Edition. 2016.
· Harrison's Principles of Internal Medicine. 19th Edition. 2015.
· 뇌졸중임상연구센터, 뇌졸중 진료지침. 개정판 2015.03.
· National Clinical Guideline for Stroke. 5th edition. 2016.
· Australian Clinical Guidelines for Stroke Management. 2017.
· AHA/ASA Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. 2014.
· Canadian Stroke Best Practice Recommendations: Secondary Prevention of Stroke, update 2017.
· ACCP Antithrombotic Therapy and Prevention of Thrombosis. 2012
· Sacco et al. Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke. N Engl J Med 2008;359:1238-51.
· Diener et al. European Stroke Prevention Study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. Journal of the Neurological Sciences 1996;143:1-13.
· ESPRIT study group et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 2006;367:1665-73.
· Malloy et al. Evaluation of Antiplatelet Agents for Secondary Prevention of Stroke Using Mixed Treatment Comparison Meta-analysis. Clin Ther. 2013;35:1490-1500.
· Bath et al. Effect of combined aspirin and extended release dipyridamole versus clopidogrel on functional outcome and recurrence in accute, mild ischemic stroke; ProFESS subgroup analysis. Stroke. 2010;41(4):732-8.
· NICE (2010.12.)
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